Job Description

Payroll Title:
SRA 1
Department:
CANCER CENTER/Hematologic Malignancies
Salary Range
Commensurate with Experience
Worksite:
Moores Cancer Center
Appointment Type:
Career
Appointment Percent:
100%
Union:
RX Contract
Total Openings:
2
Work Schedule:
Days, 8 hrs/day, Monday-Friday

As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.

#118665 Staff Research Associate I

Extended Review Date: Mon 9/26/2022

For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy

This position will remain open until a successful candidate has been identified.

UCSD Layoff from Career Appointment: Apply by 09/08/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 09/16/2022. Eligible Special Selection clients should contact their Disability Counselor for assistance.

DESCRIPTION

The Moores Cancer Center is one of just 51 in the United States to hold a National Cancer Institute (NCI) designation as a Comprehensive Cancer Center. As such, it ranks among the top centers in the nation conducting basic and clinical cancer research, providing advanced patient care and serving the community through outreach and education programs. The Cancer Center's mission is to translate promising scientific discoveries into new and better options for the care of patients with cancer. The Center supports one of the broadest ranges of cancer activities in the nation - from fundamental and translational cancer research in molecular genetics and advanced molecular therapeutics, and from population studies of cancer incidence to community education about cancer prevention and risk reduction.

Under supervision, assist with performing research techniques and research and development studies to optimize the isolation, expansion and modification of patient-derived T cells and to develop methodologies under current good manufacturing conditions (cGMP) to re-administer the cells to the donor patients.

Assist Cancer Immunotherapy Program (CIP) personnel with establishing scalable procedures to expand and transfect T-cells to form CAR-T cells and support the preclinical and clinical development of these drug candidates. These engineered T-cells will be created by the employment of a number of modern molecular biology techniques including cell transduction and transfection techniques that employ viral and nucleic acid vectors. Assist personnel with generation of clinical grade viral vector systems and the production of gene delivery systems that will be transitioned into a cGMP facility. Other duties assigned as needed.

MINIMUM QUALIFICATIONS

  • Theoretical knowledge of cell biology, immunology, biotechnology, and/or stem cell biology.

  • Theoretical and practical knowledge of biochemistry, molecular biology, immunology and genetics including relevant techniques. Knowledge of flow cytometry and FACS.

  • Experience with sterile technique and the ability to perform cell culture.

  • Experience with cellular immunology and/or tumor biology.

  • Ability to work with cellular transfection/transduction methods.

  • Ability to work with in vivo or in vitro assays systems, e.g. ELISA, Cytokine determination, ELISPOT, proliferation and cytotoxicity assays.

  • Demonstrated experience working in and maintaining a laboratory environment.

  • Proven ability to accurately keep records regarding cell lines, source, passage, and genetic manipulations. Proven ability to independently organize, analyze, and interpret data.

  • Strong communication skills (both verbal and written) needed to interact professionally and effectively in the work environment, as well as effectively and accurately document research procedures. Ability to read, comprehend and discuss research materials.

  • Experience with the operation of a personal computer, servers and software applications, such as MS Word and Excel. Knowledge to work with and learn new software for analysis.

  • Ability to follow UCSD Environmental Health and Safety requirements including the ability to write with correct syntax and grammar and to clearly communicate ideas and protocols in writing to EH&S.

PREFERRED QUALIFICATIONS

  • Ability to work with primary mammalian cell culture and with PBMC (Peripheral Blood Mononuclear Cells).
  • Enthusiasm for learning new techniques and a genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles. Ability to train students on same.
  • Experience with T-Cell biology. Experience isolating primary human T-cells from blood products using both manual and automated systems for sterile cell culture. Experience transducing and immunophenotyping primary human T-cells using aseptic technique.

SPECIAL CONDITIONS

  • Employment is subject to a criminal background check.
  • Must be able to maintain confidentiality.
  • Must be willing and able to work weekends and evenings when necessary.
  • Must be able to handle blood samples and be trained for biohazards.

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html

UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

Application Instructions

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