Job Description

Payroll Title:
Salary Range
Commensurate with Experience
Appointment Type:
Appointment Percent:
RX Contract
Total Openings:
Work Schedule:
Days, 8 hour shifts, Monday - Friday

As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.

#118255 Senior Research Associate

Extended Deadline: Tue 9/27/2022

For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy

UCSD Layoff from Career Appointment: Apply by 8/15/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 8/25/2022. Eligible Special Selection clients should contact their Disability Counselor for assistance.

Current UC San Diego Health employees who apply by 8/18/2022 will have priority consideration for this position. Recruiters will refer qualified internal candidates after the first 7 days of the job posting. All qualified external applicants and additional internal applicants who apply after the priority date may have further consideration pending the results of the initial review.


Neurodegenerative disorders like Alzheimer's and Parkinson's diseases are characterized by neuroinflammation and protein misfiling and accumulation, but also present with major disruptions in the transcriptome and epigenome, as described by our group. The work is focused on epigenetic mechanisms that govern gene expression and the alterations of these systems in Alzheimer’s disease, including circadian rhythmicity. The work involves applying cellular and mouse models, CRISPR and Cre/flox tools, in addition to cutting-edge transcription and epigenetic methodology and data analysis. Another aspect of the study is exploring epigenetic signals as biomarkers for diagnosis and disease progression, a highly-innovative project.

The Senior Research Associate will manage and coordinate research efforts with other collaborators both within and outside the laboratory. They will independently conceive, plan, and conduct research projects based on reviews of scientific literature and recent advances in related fields, organizing and executing all techniques involved. They will contribute novel ideas of major methodological significance to the research projects, design key experiments, and develop new techniques. They will author or co-author scientific journal manuscripts and book chapters, and contribute to grant writing. They will direct and advise the work of technicians, students, and postdoctoral scholars to enable them to successfully participate in laboratory projects, as well as present their findings at lab meetings and conferences, and perform other duties as needed. The will also contribute to functions necessary for the regular functioning of the lab, including some administrative and maintenance tasks.


  • Advanced theoretical knowledge of neurodegenerative diseases, epigenomics, regulation of gene transcription, circadian biology, biochemistry, and molecular biology as typically achieved by an advanced college degree and work experience.

  • Strong demonstrated experience in live- and fixed-cell imaging using confocal microscopy.

  • Strong demonstrated experience in surgery on small animals like rodents.

  • Proven experience and advanced skills in data analysis, including designing, coordinating, executing, and analyzing data from large sequencing projects and array analysis. Knowledge of the most commonly used bioinformatic tools and capacity to defined new pipelines and apply packages for analysis in R.

  • Advanced skill in experimental design and adaptation of methods to achieve results. Demonstrated experience in integrating data from multiple sources to synthesize conclusions. Knowledge and ability to read and abstract scientific articles and apply to the design of experiments.

  • Experience in providing technical work direction and training of students, post-docs, and technicians.

  • Proven experience and knowledge in developing hypotheses, design experiments, conduct experiments, analyze data, write manuscripts, and publish results in peer-reviewed journals, including all interactions with Reviewers and Editors.

  • Demonstrated experience in working with collaborators in other universities on joint projects, and working under milestones driven projects, including knowledge in writing reports.

  • Strong organizational skills, including experience in laboratory record keeping, budget analysis and managing logistics. Demonstrated knowledge of lab safety rules.

  • Proven experience in contributing and implementing innovative ideas and techniques on complex and multi-disciplinary research projects.

  • Proven ability to read scientific papers and adapt knowledge and techniques from the literature to experimental systems.

  • Excellent written, verbal and interpersonal communication skills including tack, diplomacy, and flexibility in order to work and interact effectively with staff, researchers, and management in person, on the phone or via Zoom or other video conferencing platforms.

  • Knowledge of PC software applications such as Word, Excel, PowerPoint, Keynote, Illustrator to produce reports, correspondence, graphs, and spreadsheets to generate, track, and analyze data.

  • Experience in managing the hiring and day-to-day work-flow of volunteers, undergraduate students and research technicians.

  • Prior experience performing research in a lab that studies molecular alterations in neurodegenerative diseases, including transcriptional and cell biology analysis


  • A PhD in a field related to cell biology, biochemistry or neuroscience.

  • Experience with UCSD regulations, policies, and procedures.

  • Experience with UCSD lab safety protocols.

  • Strong demonstrated experience in AAV preparation and experience in culturing, editing and differentiating human iPS cells.

  • Demonstrated experience in the official review of manuscripts for publication in peer-review journals.


  • Employment is subject to a criminal background check.

  • Occasional evenings, early hours and weekends may be required.

  • Must be willing to work with hazardous materials.

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see:

UC San Diego is a smoke and tobacco free environment. Please visit for more information.

Application Instructions

Please click on the link below to apply for this position. A new window will open and direct you to apply at our corporate careers page. We look forward to hearing from you!

Apply Online