Research Associate - 126117
#126117 Research AssociateExtended Review Date: Mon 12/4/2023
UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job opening, we strongly encourage you to apply.
This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment: Apply by 10/24/2023 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 11/02/2023. Eligible Special Selection clients should contact their Disability Counselor for assistance.
The Moores Cancer Center is one of just 52 NCI-designated Comprehensive Cancer Centers in the United States and the only one in San Diego County. As a consortium cancer center, it is a collaborative partnership between the UCSD: encompassing 14 departments (12 clinical, 2 basic sciences), 3 professional schools (School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, School of Public Health), UCSD Health oncology hospitals and clinics; the basic and public health research and outreach of San Diego State University, and the basic and translational research of the LaJolla Institute of Immunology. These various programs and units are all dedicated to fulfilling the Moores Cancer Center's mission of reducing cancer's burden. As such, it ranks among the top centers in the nation conducting the continuum of cancer research, providing advanced patient care, and serving the community through outreach and education programs.
As a top-ranking, future-oriented organization, we offer challenging career opportunities in a fast-paced and innovative environment. Moores Cancer Center Business Office follows a progressive philosophy of career-path development for its employees including opportunities for cross-training, professional development, and progressive responsibility.
Perform tumor immunology studies consisting of murine models of cancer, animal breeding and genotyping, flow cytometry, single cell sequencing, immunohistochemistry, in vitro cell biology, and in vitro biochemistry. Murine tumor biology studies will include xenograft, orthotopic and spontaneous tumor growth and metastasis assays, immunological analysis, treatment of animals with experimental therapeutic agents by gavage, intravenous and intraperitoneal methods, breeding and genotyping of transgenic and mutant mice, and immune cell isolations. Perform major surgery, including small animal anesthesia. In addition, perform immunohistochemistry of frozen and fixed tissues or cells.
Conduct various in vitro cell biology techniques to include performing flow cytometry analysis of cell surface protein expression, cell adhesion and migration assays, transfecting cells with expression constructs, preparing lysates of cells in culture or tissues, quantification, ELISA assays, SDS PAGE, Western Immunoblotting and gel electrophoresis. Additionally, perform recombinant DNA techniques to include preparing plasmids and maintaining plasmid stocks, analyzing DNA and RNA purification, and conducting DNA electrophoresis, and RT-PCR.
Make innovative contributions regarding experimental design and methodology, using published scientific data in referred journals, as well as online using search engines and subject-specific websites, to make recommended changes to current protocols and practices. Troubleshoot problems for quality control on immunochemical and histochemical procedures. Maintain and prepare accurate records of all experiments. Assist in the preparation of data for publication. Assume responsibility for lab maintenance and safety training. Provide training and work direction in areas of expertise as needed. Maintain and prepare accurate records of all experiments. Assist in the preparation of data for publication. Other duties assigned as needed.
Advanced theoretical knowledge of molecular biology, biochemistry, physiology and cell biology or a Bachelor’s of Science degree in an appropriate field of science or equivalent in education and experience.
Experience independently isolating bone marrow and blood cells for analysis by flow cytometry, immunoblotting, gene expression and cell adhesion assays.
Experience independently performing and directing in vivo experiments including the injection of growth factors, tumor cells and therapeutics, bleeding and tissue harvesting of mice and in performing minor surgery.
Experience independently performing and directing protein analysis techniques including protein determination, ELISA and Magpix assays and protein separation techniques.
Experience independently working with endothelial, myeloid and tumor cell culture, DNA and RNA isolation from culture cells and from tissues, immunoblotting and quantitative RT-PCR for genes and proteins that regulate myeloid cell adhesion, migration and gene and protein expression in vitro and in vivo.
Experience independently developing improvements to tissue culture techniques, including sterile technique, cell adhesion and migration assays.
Experience independently performing and directing molecular biological techniques, including DNA purification, genotyping and cloning.
Enthusiasm for learning and a genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles. Experience and interest in developing novel techniques and analytical methods.
Ability to use basic and advanced laboratory equipment, including centrifuges, spectrophotometers, balances pH meters, electrophoresis, single cell sequencing, magnetic and light based plate readers and flow cytometers equipment.
Willingness and ability to handle mice for surgical procedures, including anesthesia administration. Experience to maintain animal colony by breeding, genotyping and weaning animals, creating new animal strains and keeping accurate records
Strong communication skills (both verbal and written) needed to interact professionally and effectively in the work environment, as well as to effectively and accurately document research procedures. Ability to read, comprehend, and discuss research materials.
Ability to adhere to established UCSD guidelines for safety and environmental issues.
Experience with personal computers, including word processing and spreadsheets. Ability to use Quartzy and Oracle to place and reconcile orders and receipts.
Experience managing laboratory, including directing students, employees and volunteers, ordering and maintaining inventory, organizing and maintaining freezers, cold room, and equipment.
Knowledge to manage official travel and entertainment documentation and file reimbursements requests.
Demonstrated knowledge in making innovative contributions to experimental design and methodology by reviewing.
Interest and ability to teach students, postdocs and new personnel methods and skills.
- Employment is subject to a criminal background check.
- Must be willing to work frequently with animals and to work occasional nights and weekends.
- Proven ability to work with animals, willingness to work with biohazardous materials.
Pay Transparency Act
Annual Full Pay Range: $64,506 - $103,727 (will be prorated if the appointment percentage is less than 100%)
Hourly Equivalent: $30.89 - $49.68
Factors in determining the appropriate compensation for a role include experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. The Hiring Pay Scale referenced in the job posting is the budgeted salary or hourly range that the University reasonably expects to pay for this position. The Annual Full Pay Range may be broader than what the University anticipates to pay for this position, based on internal equity, budget, and collective bargaining agreements (when applicable).
If employed by the University of California, you will be required to comply with our Policy on Vaccination Programs, which may be amended or revised from time to time. Federal, state, or local public health directives may impose additional requirements.
If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.
UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!
Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.
To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.
UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html
UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.
UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening.