Staff Research Associate I - 115582
As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.
#115582 Staff Research Associate IExtended Review Date: Thu 5/19/2022
For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy
This position will remain open until a successful candidate has been identified.
UCSD Layoff from Career Appointment: Apply by 04/14/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 04/25/2022. Eligible Special Selection clients should contact their Disability Counselor for assistance.
The Moores Cancer Center is one of just 50 in the United States to hold a National Cancer Institute (NCI) designation as a Comprehensive Cancer Center. As such, it ranks among the top centers in the nation conducting basic and clinical cancer research, providing advanced patient care and serving the community through outreach and education programs.
The Cancer Center's mission is to translate promising scientific discoveries into new and better options for the care of patients with cancer. The Center supports one of the broadest ranges of cancer activities in the nation - from fundamental and translational cancer research in molecular genetics and advanced molecular therapeutics, and from population studies of cancer incidence to community education about cancer prevention and risk reduction.
Under supervision, assist with performing research techniques, and troubleshooting new and established assay techniques. Assist with performing and analyzing in vivo and in vitro experiments to study expression of receptor tyrosine kinase like orphan receptor 1 (ROR1) and ROR2 in ovarian, breast, and lung cancer and to define role of ROR1 in promoting tumor growth, metastasis, and tumor initiation using primary cancer cells and cell lines. Assist with conducting a phase 1b pilot clinical trial of cirmtuzumab (an anti-ROR1 mAb) in combination with paclitaxel for the treatment of patients with metastatic, or locally advanced, unresectable breast cancer. Assist in pharmaceutical kinetic and pharmaceutical dynamic studies for anti-cancer drugs.
Theoretical knowledge of immunology, molecular biology, cell biology, and protein chemistry.
Ability to perform standard molecular biology techniques, including PCR, SDS Page electrophoresis, western blotting, ELISA assays, and recombinant DNA manipulation.
Knowledge of various mice handling techniques.
Knowledge of various cell based assays pertaining to investigating cancer stem cell hypothesis.
Ability to culture primary tumor cells and cancer stem cells in vitro. Knowledge of cancer stem cells.
Knowledge and experience in flow cytometry and operation of a FACS calibur instrument. Ability to assist with performing and interpreting results from experiments with human and mouse cells stained with specific fluorochrome-conjugated monoclonal antibodies.
Knowledge and willingness to handle blood, plasma and other human specimens for processing and shipping. Must be willing and able to work with human samples, animals, and biohazardous materials.
Excellent interpersonal and oral communication skills. Skill to effectively and clearly communicate with tact, diplomacy, discretion, and flexibility to faculty, academicians, students, and staff including those of diverse ethnicity, culture, and foreign nationals. Ability to present information clearly and concisely.
- Knowledge of the cancer stem cell hypothesis and markers, particularly as it pertains to ovarian cancer, breast cancer, and lung cancer.
- Ability to establish patient-derived xenograft (PDX) including subcutaneous injection model and orthotopic mice model.
- Experience working with solid tumors, including breast and ovarian cancer.
- Experience in mice orbital bleeding for various studies relating to anti-cancer drugs.
- Employment is subject to a criminal background check.
- Must be willing and able to work holidays, weekends and evenings when necessary.
- Must be able to handle blood samples and be trained for biohazards.
Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).
UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!
Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.
UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html
UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.