Job Description

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Commensurate with Experience
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Days, 8 hour shifts, Monday - Friday

As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.

#118762 Research Development Engineer

Extended Review Date: Tue 10/25/2022

UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job opening, we strongly encourage you to apply.

For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy

UCSD Layoff from Career Appointment: Apply by 9/14/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 9/23/2022. Eligible Special Selection clients should contact their Disability Counselor for assistance.


The mission of the Center for Epigenomics at UC San Diego is to develop a quantitative and molecular framework to study the function and regulation of the human genome, with the ultimate goal to understand the molecular basis of cancer and other human diseases. Epigenomics is at the forefront of Precision Medicine. The epigenome, a term referring to the state of DNA methylation and the covalent modifications of histone proteins in a cell, plays a central role in regulating the functional output of the genome during development. Changes in the epigenome that result from exposure to stress, pathogenic conditions, and aging can determine the patterns of gene expression and predispose an individual to diseases. Epigenome research promises to significantly improve our understanding of the factors that drive human development and disease. The UCSD Center for Epigenomics works with researchers on the UCSD campus and beyond to foster the application of epigenomic concepts and technologies to clinical, translational, and basic research.

The newest Spatial and Functional Genomics technology platform of the Center focuses on profiling epigenomics in their native tissue context to understand each cell’s function. We have implemented latest epigenomic robotics and analytical tools to acquire spatial genomics information on gene regulation and chromatin organization. Under the direction of the Associate Director, the R&D Engineer will facilitate to set up a platform for high-throughput imaging and functional genomics. The incumbent will play a key role in maintaining and upgrading the advanced Fluorescence In Situ Hybridization (FISH)-based imaging technologies to conduct high throughput, spatially resolved single cell analysis of transcriptomics and chromatin structure. The incumbent will perform integration and testing of subsystems such as fluidics system, imaging system, control software, and image analysis. The incumbent will collect data, analyze data, present findings, trouble shoot, maintain the system performance and improve system performance. The incumbent will work with other researchers to perform experiments using the established imaging system. Additionally, the incumbent will help to maintain the computer network and assist with data storage and management. Demonstrates good judgment in selecting methods and techniques for obtaining solutions

CT - Uses professional engineering concepts to perform moderately complex engineering assignments. Works in a specialized engineering field on a major training and / or research effort. Works on assignments of moderate scope where analysis of situations or data requires a review of a variety of factors.


  • 6 years of related experience, education/training, OR a Bachelor's degree in related area in bioengineering, physics, electric engineering, computer engineering plus 2 years of related experience/training.

  • Working knowledge of engineering principles and methods in order to independently perform professional engineering design work of limited scope and complexity. Background in optical science and engineering, with comprehensive optics and system knowledge. Demonstrated knowledge of precision optical system design, understanding and practical knowledge of microscopic imaging system and experience of system level design. Experience with various optical components including lightsource, sensors, and imaging modalities, and opto-mechanical integration.

  • Working knowledge necessary to begin independent application of principles, practices and procedures in the completion of assignments. Experience or ability to design microfluidics systems including integrated micro channel systems with pumps/valves, microchannel flow characterization methods. Experience with assembling fluidics systems for characterization and implement control/automation routines using software.

  • Organizational abilities and decision-making to prioritize work assignments.

  • Effective written and verbal communication skills. Excellent skill in Word, PowerPoint, Excel, Image J.

  • Ability to work in a collaborative manner, to assist in identifying any challenges or barriers. Ability to carry out data analysis using scripts written in Python or Matlab, troubleshooting and problem solving in building complex and interdisciplinary instruments. Knowledge or experience with image processing for fluorescence microscopic images. Deep knowledge of high-throughput instrumentation methods for biological studies.

  • Demonstrated organizational and decision-making abilities to prioritize competing work assignments in order to meet deadlines and adherence to quality standards.

  • Ability to play a key role in maintaining FISH-based imaging technologies to conduct high throughput, spatially resolved single cell analysis of transcriptomics and chromatin structure.


  • Familiar with advanced microscopy technology, such as super-resolution microscopy, light-sheet microscopy, etc. is a plus.


  • Employment is subject to a criminal background check.

  • Occasional evenings and weekends may be required.

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see:

UC San Diego is a smoke and tobacco free environment. Please visit for more information.

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