Neurological Disorders Technician - 112512
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#112512 Neurological Disorders TechnicianFiling Deadline: Thu 2/3/2022
For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy
UCSD Layoff from Career Appointment: Apply by 11/01/2021 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
This position will remain open until filled.
The Department of Neurosciences has a large research group studying neuro-degenerative diseases in the lab of Dr. Robert Rissman.
Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neuro-degenerative disorders have begun to clarify pathogenetic mechanisms of disease. We examine the intersection of these research themes and identify several potential mechanisms for linking failed neurotrophic factor signaling to neurodegeneration. We will be expanding our research group and are looking for a Staff Research Associate to support our efforts.
Incumbent will be independently responsible for the dissection of fresh or fixed human brains including tissue preparation and processing, fulfilling tissue requests, logging and recording specimen data, as well as overseeing Alzheimer's Disease and Neurodegeneration tissue/brain bank. Incumbent will carry out experiments aimed at understanding the molecular mechanisms involved in neurodegeneration in neurological disorders such as Alzheimer's Disease, Parkinson's Disease and HIV including tissue culture analysis followed by real time PCR, Western blots, immunoprecipitation and cell assays. Additional duties include maintain lab stocks of chemicals and supplies, accurate and detailed lab notebook and other records, and attending weekly lab meetings.
Theoretical knowledge in cell biology, chemistry and molecular genetics as typically acquired by a Bachelor's degree, or an equivalent combination of education and experience.
Experience in molecular biology including: RNA/DNA isolation, Real-time PCR, bacterial transformation, Western blot, and tissue culture.
Experience producing high quality vibratome sections for confocal microscopy and high quality thin and semi-thin sections for electron microscopy.
Experience processing human and murine brain tissue for immunocytochemical assays and western blots, and electron microscope.
Knowledge of neurological disorders such as Alzheimer's Disease, Parkinson's Disease and HIV.
Experience with and knowledge of the operation and maintenance of various laboratory equipment such as confocal, fluorescent, and electron microscopes, centrifuges, plate readers, microtomes, and vibratomes.
Experience preparing buffers and solutions.
Strong computer skills and experience with the operation of all basic software application such as Word and Excel, as well as knowledge and ability to work with a variety of statistical and analysis programs, and learn specialized imaging and analysis software.
Excellent communication skills (both verbally and written) to interact professionally and effectively in a basic research work environment, as well as accurately document research procedures that facilitate professional and effective interaction with a diverse population. Ability to comprehend and discuss research materials.
Experience performing accurate record keeping and organize and calculate data. Skill to plan and organize work assignments in a efficient and productive manner.
Excellent interpersonal skills including tact, diplomacy and flexibility. Ability to work independently and/or in a team framework in conjunction with principles of community and in a lab environment that interacts with a diverse group of research and technical personnel and other laboratories.
Experience and knowledge to read and use Material Safety Data Sheets.
Experience in genotyping and Fluorescence-Activated cell sorting.
Knowledge of basic lab safety requirements, procedures, and ability to follow EH&S regulations and methods for handling, inventory, storing, clean-up, and waste disposal for biohazardous materials. Ability to maintain safe and orderly laboratory. Ability to maintain inventories and order supplies for lab.
- Knowledge of UCSD Environmental Health and Safety requirements including radiation and biosafety procedures.
- Basic knowledge of virology and practical knowledge in molecular methods and lentivirus production.
- Employment is subject to a criminal background check.
- Must be willing to work with radioactive and hazardous materials.
- Must be willing to work with HIV/AIDS materials in a research environment.
- Must be available to work some weekends and evenings to complete experiments.
Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).
UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!
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