Job Description

Payroll Title:
Hiring Pay Scale
$32.81 - $52.81 / Hour
La Jolla
Appointment Type:
Appointment Percent:
RX Contract
Total Openings:
Work Schedule:
Days, 8 hour shifts, Monday - Friday

#122092 Electrophysiologist

Filing Deadline: Tue 3/28/2023

UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job opening, we strongly encourage you to apply.

For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy

UCSD Layoff from Career Appointment: Apply by 03/16/2023 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 03/28/2023 Eligible Special Selection clients should contact their Disability Counselor for assistance.

Placement within the salary range is determined by internal equity, relevant qualifications, and collective bargaining agreements (when applicable).


Under the general supervision of the Principal Investigator (PI), incumbent will perform independent research as an Electrophysiologist for a Neurosciences laboratory focusing on experiments using rodent models of Parkinson Disease and Alzheimer's Disease (AD). Experiments will involve preparing acute brain slices from aged mice and intracellular and extracellular recordings in the prepared slices using different combinations of stimulating and recording electrodes. Responsibilities will include experimental design and troubleshooting. Incumbent will select specific methods to achieve the objectives and contribute original ideas of major methodological significance to the investigation preceding both the references to the general body of scientific knowledge and by application of trial and error methods. Other experiments might involve molecular biology, fluorescence imaging and immunohistochemistry.

Incumbent will independently design and execute experiments to further understand the biology and impact of astrocyte to neuron conversion and the expression and impact on neurons of expression of PTBP1 and PTBP2 in order to meet existing grant objectives/milestones and other funding objectives that support Alzheimer's disease in order to meet existing grant objectives/milestones and other funding objectives that support Parkinson and Alzheimer's disease research. Incumbent will manage and coordinate research efforts with other collaborators as appropriate for multidisciplinary research. Will plan, execute and follow-up on high level regular and ad hoc meetings of investigators and management.

Incumbent will independently conceive, plan, and conduct research projects based on reviews of scientific literature and recent advances in related fields, organizing and executing all techniques involved. Will contribute novel ideas of major methodological significance to the research projects, designing key experiments and developing new techniques. Incumbent will author or co-author scientific journal manuscripts and book chapters. Will assist in reports to funding agencies. Additional responsibilities to include preparation and implementation of research study budgets based on analysis of data, direct and advise the work of technicians, students, and post-doctoral fellows to enable them to successfully participate in laboratory projects, and perform other duties as needed.


  • Extensive theoretical knowledge in neurosciences, and five (5+) or more years of experience in brain slice electrophysiology, or equivalent combination of education and experience that includes PhD and Post-Doctoral experience.

  • Proven ability to perform independent scientific inquiry and to provide significant independent contribution, original ideas and implement innovative ideas/techniques on complex and multi-disciplinary research projects.

  • Highly trained in electrophysiology and acute brain slice preparation in rodents.

  • Advanced technical competence in a wide variety of data processing and analysis techniques.

  • Able to set up and use a new electrophysiological instrumentation.

  • Proven experience in electrophysiological techniques including intracellular whole-cell patch-clamp recordings in cortical and hippocampal slices in rodents.

  • Demonstrated ability to independently contribute to experimental design, analysis and interpretation of results.

  • Extensive experience in analysis of synaptic plasticity experiments.

  • Demonstrated ability in troubleshooting of electrophysiology equipment and methods. Might include small device design and implementation.

  • Working knowledge of standard research animal-use protocols.

  • Ability to make independent decisions, analyze situations, solve problems, and initiate actions for effective research. Strong analytical and critical thinking skills to identify problems and develop innovative solutions

  • Proven skill in technical writing and demonstrated ability to write and/ or assist with writing of manuscripts forpublication. Ability to read, comprehend and discuss research materials.

  • Advanced skills in electrophysiological acquisition and analysis software pClamp/Clampfi, Igor and MiniAnalyis.

  • Excellent interpersonal skills including tact, diplomacy and flexibility with the ability to work well independently or in a team framework in conjunction with principles of community with staff, faculty, researchers, and other lab personnel.

  • Detail oriented, highly efficient, productive, and collaborative with mentoring skills.

  • Proven knowledge of basic lab safety requirements/procedures; EH&S regulations and methods for handling, clean-up, and waste disposal for biohazardous materials.

  • Strong computer skills using MS Word, Excel, PowerPoint, statview on Apple and PC, email system, and a variety of web-based programs. Ability to create and maintain databases and learn new programs and applications with minimal direction. Commitment to update/maintain technology skills with relevant computer software.


  • Experience in studies of disease biology.


  • Employment is subject to a criminal background check.
  • Must be willing to work with biohazardous materials.
  • Must be willing to work with rodents.
  • Must be willing to work flexible schedule in order to complete experiments as necessary.

Pay Transparency Act

Annual Full Pay Range: $68,517 - $110,273 (will be prorated if the appointment percentage is less than 100%)

Hourly Equivalent: $32.81 - $52.81

Factors in determining the appropriate compensation for a role include experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. The Hiring Pay Scale referenced in the job posting is the budgeted salary or hourly range that the University reasonably expects to pay for this position. The Annual Full Pay Range may be broader than what the University anticipates to pay for this position, based on internal equity, budget, and collective bargaining agreements (when applicable).

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see:

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Application Instructions

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