Job Description

Payroll Title:
Medicine/Endocrinology & Metabolism
Hiring Pay Scale
$29.85 - $48.00 / Hour
La Jolla
Appointment Type:
Appointment Percent:
RX Contract
Total Openings:
Work Schedule:
Days, 8 hrs/day, Monday-Friday

#126050 Cardiovascular Physiologist:Staff Research Associ

Initial Review Date: Fri 10/27/2023

UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job opening, we strongly encourage you to apply.

UCSD Layoff from Career Appointment: Apply by 10/17/2023 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 10/27/2023. Eligible Special Selection clients should contact their Disability Counselor for assistance.


The Department of Medicine (DOM) is the largest department within the UCSD School of Medicine and is responsible for fulfilling the teaching, research and clinical missions of the University of California, San Diego School of Medicine. The department employs approximately 500 salaried faculty, 168 academic appointees, 331 residents, fellows and postdocs and 480 staff personnel.

The cardiovascular research laboratory in the Department of Medicine at the University of California, San Diego, seeks a Staff Research Associate 3 (SRA3) who is highly motivated, creative, and devoted to the project goals. One position in cardiovascular physiology is immediately available. Our research focuses on endothelial dysfunction in the heart and lung during cardiovascular diseases. The incumbent will design and implement research protocols and conduct experiments for ongoing research projects in the laboratory. Duties and Responsibilities are 1) perform physiological experiments in mice, including evaluation of cardiac function using Millar system (e.g., RVSP, LVSP, dP/dt, EF), measurement of pulmonary and coronary flow using an ultrasound system, and isometric tension measurements in mouse distal pulmonary and coronary arteries using a wire myograph, 2) conducting molecular biological experiments (e.g., Western Blot, immunoprecipitation, PCR, qPCR, gene cloning), 3) electrophysiological experiments to measure Ca2+ and ROS concentration in cytoplasm and mitochondria and assess GAP junction intercellular communication, 4) immunofluorescence experiment, and 5) isolation of vascular endothelial/smooth muscle cells from mouse lungs and hearts.

The incumbent will perform data acquisition and analysis, grant and manuscript preparation, and presentation of findings at weekly lab meetings. Additional responsibilities include maintaining transgenic mice colonies (i.e., breeding and genotyping), managing lab research records (e.g., methodological approaches, experimental records, and protocols), and maintaining a clean lab and the function of lab equipment. Aseptic techniques for tissue culture and animal handling are mandatory skills in our laboratory.


  • Theoretical and working knowledge in advanced molecular biology and cell physiology.

  • Minimum three (3) years of paid work in the field of cardiovascular physiology.

  • Proven skills in physiological experiments in mice, including measurements of cardiac functions using the Millar system (e.g., RVSP, LVSP, dP/dt, EF), assessment of pulmonary and coronary flow using an ultrasound system, or isometric tension measurements in mouse distal pulmonary and coronary arteries using a wire myograph.

  • Strong ability and experience to isolate heart and lung vascular endothelial and smooth muscle cells and prepare primary cultured cells for molecular biological and cell physiological experiments.

  • Experiences in conducting electrophysiological and immunofluorescence experiments using a fluorescence microscope.

  • Demonstrated ability and experience in Western Blot, immunoprecipitation, site-directed mutagenesis, PCR, qPCR, and single-cell RT-PCR.

  • Ability to maintain transgenic mice colony, including breeding and genotyping.

  • Proven ability to contribute to experimental design, analysis, interpretation of the results, and troubleshooting.

  • Experience assisting with scientific writing, including research articles, review articles, and necessary grant protocols.

  • Strong ability to read scientific literature, understand appropriate study design, follow study procedures and protocol, and maintain participant confidentiality.

  • Demonstrated skills in working with animals, human tissues, and aseptic techniques for cell culture.

  • Proficient knowledge of the following specialized programs; EndNote and MS Word/Excel/PowerPoint.

  • Enthusiasm for learning and a genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles.

  • Effective and diplomatic oral and written communication and interpersonal skills. Ability to work with various personnel from different laboratories and instruct in optimal procedures for assays.

  • Skills to manage the lab research records, including methodological approaches, experimental records, IACUC, IBC, and IRB protocols, order and chemical inventories, and animal colony records, and maintain a clean lab and the function of lab equipment.


  • Must be able to work with laboratory animals (mice).
  • Must be available to work some weekends & evenings to complete experiments.
  • Employment is subject to a criminal background check.

Pay Transparency Act

Annual Full Pay Range: $64,506 - $103,727 (will be prorated if the appointment percentage is less than 100%)

Hourly Equivalent: $30.89 - $49.68

Factors in determining the appropriate compensation for a role include experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. The Hiring Pay Scale referenced in the job posting is the budgeted salary or hourly range that the University reasonably expects to pay for this position. The Annual Full Pay Range may be broader than what the University anticipates to pay for this position, based on internal equity, budget, and collective bargaining agreements (when applicable).

If employed by the University of California, you will be required to comply with our Policy on Vaccination Programs, which may be amended or revised from time to time. Federal, state, or local public health directives may impose additional requirements.

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see:

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UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening.

Application Instructions

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