Cardiovascular Physiologist: SRA - 118518
#118518 Cardiovascular Physiologist: SRAInitial Review Date: Wed 12/7/2022
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The Department of Medicine (DOM) is the largest department within the UCSD School of Medicine and is responsible for fulfilling the teaching, research and clinical missions of the University of California, San Diego School of Medicine. The department employs approximately 500 salaried faculty, 168 academic appointees, 331 residents, fellows and postdocs and 480 staff personnel.
The cardiovascular research laboratory in the Department of Medicine at the University of California, San Diego, seeks a Staff Research Associate 3 (SRA3) who is highly motivated, creative, and devoted to the project goals. One position in cardiovascular physiology is immediately available. Our research focuses on endothelial dysfunction in the heart and lung during cardiovascular diseases. The incumbent will design and implement research protocols and conduct experiments for ongoing research projects in the laboratory. Duties and Responsibilities are 1) perform physiological experiments in mice, including evaluation of cardiac function using Millar system (e.g., RVSP, LVSP, dP/dt, EF), measurement of pulmonary and coronary flow using an ultrasound system, and isometric tension measurements in mouse distal pulmonary and coronary arteries using a wire myograph, 2) conducting molecular biological experiments (e.g., Western Blot, immunoprecipitation, PCR, qPCR, gene cloning), 3) electrophysiological experiments to measure Ca2+ and ROS concentration in cytoplasm and mitochondria and assess GAP junction intercellular communication, 4) immunofluorescence experiment, and 5) isolation of vascular endothelial/smooth muscle cells from mouse lungs and hearts. The incumbent will perform data acquisition and analysis, grant and manuscript preparation, and presentation of findings at weekly lab meetings. Additional responsibilities include maintaining transgenic mice colonies (i.e., breeding and genotyping), managing lab research records (e.g., methodological approaches, experimental records, and protocols), and maintaining a clean lab and the function of lab equipment. Aseptic techniques for tissue culture and animal handling are mandatory skills in our laboratory.
Theoretical and working knowledge in advanced molecular biology and cell physiology.
Aseptic techniques for cell culture.
Demonstrated ability to contribute to experimental design, analysis, interpretation of the results, and troubleshooting.
Demonstrated experience assisting with writing scientific manuscripts and contributing to teamwork in molecular biological experiments.
Demonstrated ability and experience to isolate heart and lung vascular endothelial and smooth muscle cells and prepare primary cultured cells for molecular biological and cell physiological experiments.
Demonstrated ability and experience in Western Blot, immunoprecipitation, site-directed mutagenesis, PCR, qPCR, and single-cell RT-PCR.
Demonstrated ability and experience in electrophysiological experiments and immunofluorescence experiments using a fluorescence microscope.
Demonstrated skill to work with animals, as well as animal and human tissues.
Demonstrated knowledge of the following specialized programs; SnapGene, GraphPad, EndNote, and MS Word/Excel/PowerPoint.
Demonstrated ability to read scientific literature, understand appropriate study design, follow study procedures and protocol, and maintain participant confidentiality.
Demonstrated effective time management skills to plan and organize work assignments in an efficient and productive manner.
Enthusiasm for learning and a genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles.
Effective and diplomatic oral and written communication and interpersonal skills. Ability to work with a variety of personnel from different laboratories and instruct in optimal procedures for assays.
Perform physiological experiments in mice, including evaluation of cardiac function using Millar system (e.g., RVSP, LVSP, dP/dt, EF), measurement of pulmonary and coronary flow using an ultrasound system, and isometric tension measurements in mouse distal pulmonary and coronary arteries using a wire myograph.
Conduct electrophysiological experiments to measure Ca2+ and ROS concentration in cytoplasm/ER/mitochondria, and Gap junction intercellular communication.
Employment is subject to a criminal background check.
Must be available to work some weekends & evenings to complete experiments.
Must be able to work with laboratory animals (mice).
Pay Transparency Act Full Salary Range: $62,324 - $100,220 Annually
The University of California, San Diego is required to provide a reasonable estimate of the compensation range for this role. This range takes into account the wide range of factors that are considered in making compensation decisions including but not limited to experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be offered a salary at or near the top of the range for a position. Salary offers are determined based on final candidate qualifications and experience. The full salary range for this position is defined as the Full Pay Range. The budgeted salary or hourly range that the University reasonably expects to pay for this position defined as the Expected Pay Scale. Placement within the Expected Pay Scale is determined by internal equity, relevant qualifications, and collective bargaining agreements (when applicable).
Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).
If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.
UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!
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