Associate Director of the Functional Genomics Plat - 116386
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#116386 Associate Director of the Functional Genomics PlatFiling Deadline: Fri 5/27/2022
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The mission of the UCSD Center for Epigenomics is to develop a quantitative and molecular framework to study the function and regulation of the human genome, with the ultimate goal to understand the molecular basis of cancer and other human diseases. This center aims to be a world class research organization focused on making discoveries about the regulation and function of the human genome, developing innovative technologies and computational tools, and translating fundamental knowledge about gene regulation into improved clinical outcomes.
Epigenomics is at the forefront of Precision Medicine. The epigenome, a term referring to the state of DNA methylation and the covalent modifications of histone proteins in a cell, plays a central role in regulating the functional output of the genome during development. Changes in the epigenome that result from exposure to stress, pathogenic conditions and during aging can determine the patterns of gene expression and predispose an individual to diseases. Epigenome research promises to significantly improve our understanding of the factors that drive human development and disease. The UCSD Center for Epigenomics will work with researchers on the UCSD campus and beyond to foster the application of epigenomic concepts and technologies to clinical, translational, and basic research.
The Single Cell Genomics Platform is one of three technology platforms in the UCSD Center for Epigenomics. This technology platform is focused on implementation of cutting-edge technologies, including single cell RNA-seq and single cell ATAC-seq, for studying genome function in single cells from complex tissue samples and cell culture models. In addition, this technology platform is also going to develop new tools to advance single cell genomic studies in various biological samples. Under the direction of the Center’s Director, the Associate Director of Single Cell Genomics will oversee a team of technicians and bioinformaticians in the application and development of single cell genomics assays to address key questions about gene regulation in development and disease. The incumbent will be responsible for training and direct supervision of staff in the Single Cell Genomics Platform.
The incumbent will work with other campus investigators to design research projects that make use of the Single Cell Genomics Platform, and will oversee the day-to-day execution of these research projects. Research projects may be structured as collaborative, fee-for-service, or internal to the center. The incumbent will ensure that the single cell genomics technologies within the center are maintained at the cutting edge of the field, and work with other stakeholders to design, develop, and engineer specialized single cell genomics workflows.
The incumbent will represent the center and foster growth by giving seminars, attending meetings and conferences, building relationships with campus investigators, and seeking strategic partnerships. The incumbent will also write major parts of scientific grant proposals and publications.
Independently oversees a medium sized academic or research program and represents the program to outside organizations. Oversees all administrative operations, finance, human resources and facilities for program. Designs and develops major program components, and administers the full range of the program's operational requirements. Works with faculty on formulating short-term planning and procedures. Develops and organizes conferences and other public forums. Works under direction of Principal Investigator to establish center agenda, funding, objectives.
Academic background and experience in selected area of research. Ph.D. in a relevant field preferred. At least five or more (5+) of relevant post degree experience required. Expertise in the fields of Epigenomics, Gene Regulation, Functional Genomics, mammalian cell culture, virology, high throughput reporter assays as evidenced by a strong record of relevant scientific publications.
Thorough knowledge of administrative, budgetary, human resources and financial principles and practices.
Excellent oral and written communication skills. as demonstrated by an extensive record ofpublications, presentations, and successful collaborative efforts.
Hands-on experience with genomic assays such as ChIP-seq, and RNA-seq. Deep knowledge of AAV mediate transfection, and reporter assays. The candidate should have a major grasp of areas such as high-throughput reporter assays and high throughput genome editing and functional characterization assays.
Effective interpersonal skills and ability to work with diverse groups to achieve results.
Ability to develop and nurture working partnerships in an academic environment with technical staff and research participants.
Ability to work collaboratively with internal and external peers and managers. Extensive collaborative experience in the planning, development, and implementation of largeresearch projects.
Proven experience applying new technological advances to biological questions. Demonstration of management skills in a data production and a complex technology environment.
Demonstrated ability to think creatively and independently on concepts requiring advanced analytical skills.
Highly skilled fundraising experience.
- Irregular hours or on weekends/holidays as required.
- Willing to work in an environment with biological, chemical and radiological hazards, and with human Embryonic Stem Cells and animal models.
- Occasional travel.
- Job offer is contingent upon satisfactory clearance based on Background Check results.
Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).
UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!
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