Job Description

Payroll Title:
Salary Range
Commensurate with Experience
La Jolla
Appointment Type:
Appointment Percent:
RX Contract
Total Openings:
Work Schedule:
Days, 8 hrs/day, Monday - Friday

As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.

#111325 Lab Manager/Research Associate

Initial Review Date: Mon 10/11/2021

For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus before they will be allowed on campus or in a facility or office. For more information visit:,-faculty-and-staff-issued-for-2021-2022.html

UCSD Layoff from Career Appointment: Apply by 08/27/21 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 09/07/21. Eligible Special Selection clients should contact their Disability Counselor for assistance.


Under supervision, this position will support research related to amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease" and related neurodegenerative disorders. This position will oversee a neuropathological tissue repository and require tissue management including gross dissection, tissue freezing, fixation, paraffin embedding, microtome, crystat cutting, routine neuropathological staining, and molecular pathology (IF, IHC, ISH on human brain and spinal cord). In addition, the position requires overall lab management including supply inventory and equipment maintenance. There is need for and opportunity to support mouse experiments and to support cell culture, molecular biology of gene expression, and biochemistry.

Responsibilities may include production and maintenance of cell lines, perform various molecular biology techniques (PCR, RNA profiling and amplification, expression profiling). ALS Researcher will examine, photograph, and analyze resultant material on light, fluorescent, and confocal microscopes. Importance is given to ability to collaborate and work with others in the lab, share expertise, teach others, and stay abreast with current publications and research findings, and learn new techniques through mentoring and support. Additional duties include participate in planning and sequencing of work, meticulous recordkeeping, archiving of biological specimens, data analysis and general lab duties including but not limited to, lab cleanliness, ordering supplies and equipment, and lab safety.

This job is posted as 60%-variable to ensure the employee will have benefits but also have flexibility of work schedule--funding is available for full time (100%) work.


  • Knowledge and expertise in molecular neuropathology.

  • Working knowledge of amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease, ALS pathology, neuroanatomy of motor system, spinal cord anatomy and histology, molecular biology or related field esp. RNA biology and gene expression.

  • Experience to independently oversee neuropathology tissues including fixation, embedding, sectioning and performing routine histology, including prepare staining solutions and buffers, IHC, IF, and microscopy.

  • Experience with cell cultures to maintain and create cell lines and all technical aspects needed for this, such as media prep, supply materials standard media supplies, and supply requisition.

  • Experience to independently perform tissue acquisition at autopsies including tissue processing for downstream applications, de-identifying and archiving acquired tissues and materials and proper handling of cadaver including identification and notification of authorities and meticulous tracking while under research authority.

  • Experience to perform routine experiments with attention to detail, analyze results, and provide accurate documentation, and to write papers for publication.

  • Strong verbal, written, and electronic communication skills that facilitate professional, effective, and courteous interaction both within the lab group and with diverse collaborators.

  • Outstanding interpersonal skills including tact, diplomacy and flexibility with the ability to work in a team framework in conjunction with principles of community with staff, faculty and students. Promote effective and respective interactions essential to foster and enliven research and academics.

  • Computer skills using MS Word, Excel, PowerPoint, email system, and a variety of web-based programs. Ability to create and maintain databases, perform standard computer tasks, learn new programs/applications with minimal direction

  • Effective time-management to efficiently plan and sequence and "level-load" or pace the work and experiments by the priority of the project and the time-demands.

  • Experience in performing all aspects of general lab maintenance including ordering and maintaining laboratory equipment and supplies.

  • Working knowledge of basic lab safety requirements and EH&S procedures.


  • Employment is subject to a criminal background check.

  • Must be willing to work overtime and with a varied work schedule to complete experiments/projects when necessary.

Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).

UC San Diego Health is the only academic health system in the San Diego region, providing leading-edge care in patient care, biomedical research, education, and community service. Our facilities include two university hospitals, a National Cancer Institute-designated Comprehensive Cancer Center, Shiley Eye Institute, Sulpizio Cardiovascular Center, and several outpatient clinics. UC San Diego Medical Center in Hillcrest is a designated Level I Trauma Center and has the only Burn Center in the county. We invite you to join our dynamic team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see:

UC San Diego is a smoke and tobacco free environment. Please visit for more information.

Application Instructions

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