111325 - ALS/Neuropathology Research Assoc./ Lab Manager
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#111325 ALS/Neuropathology Research Assoc./ Lab ManagerFiling Deadline: Mon 10/11/2021
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UCSD Layoff from Career Appointment: Apply by 8/27/21 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants: Apply by 9/7/21. Eligible Special Selection clients should contact their Disability Counselor for assistance.
Under supervision, this position will support research related to amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease" and related neurodegenerative disorders. This position will oversee a neuropathological tissue repository and require tissue management including gross dissection, tissue freezing, fixation, paraffin embedding, microtome, crystat cutting, routine neuropathological staining, and molecular pathology (IF, IHC, ISH on human brain and spinal cord). In addition, the position requires overall lab management including supply inventory and equipment maintenance. There is need for and opportunity to support mouse experiments and to support cell culture, molecular biology of gene expression, and biochemistry. Responsibilities may include production and maintenance of cell lines, perform various molecular biology techniques (PCR, RNA profiling and amplification, expression profiling). ALS Researcher will examine, photograph, and analyze resultant material on light, fluorescent, and confocal microscopes. Importance is given to ability to collaborate and work with others in the lab, share expertise, teach others, and stay abreast with current publications and research findings, and learn new techniques through mentoring and support. Additional duties include participate in planning and sequencing of work, meticulous recordkeeping, archiving of biological specimens, data analysis and general lab duties including but not limited to, lab cleanliness, ordering supplies and equipment, and lab safety.
This job is posted as 60%-variable to ensure the employee will have benefits but also have flexibility of work schedule--funding is available for full time (100%) work.
Knowledge and expertise in molecular neuropathology.
Working knowledge of amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease, ALS pathology, neuroanatomy of motor system, spinal cord anatomy and histology, molecular biology or related field esp. RNA biology and gene expression.
Experience to independently oversee neuropathology tissues including fixation, embedding, sectioning and performing routine histology, including prepare staining solutions and buffers, IHC, IF, and microscopy.
Experience with cell cultures to maintain and create cell lines and all technical aspects needed for this, such as media prep, supply materials standard media supplies, and supply requisition.
Experience to independently perform tissue acquisition at autopsies including tissue processing for downstream applications, de-identifying and archiving acquired tissues and materials and proper handling of cadaver including identification and notification of authorities and meticulous tracking while under research authority.
Demonstrated ability and willing to learn new techniques as need arises by self-study, seeking mentors, taking precautions, comparing information and experiences to improve and refine these for optimal performance.
Experience to perform routine experiments with attention to detail, analyze results, and provide accurate documentation, and to write papers for publication.
Strong verbal, written, and electronic communication skills that facilitate professional, effective, and courteous interaction both within the lab group and with diverse collaborators.
Outstanding interpersonal skills including tact, diplomacy and flexibility with the ability to work in a team framework in conjunction with principles of community with staff, faculty and students. Promote effective and respective interactions essential to foster and enliven research and academics.
Computer skills using MS Word, Excel, PowerPoint, email system, and a variety of web-based programs. Ability to create and maintain databases, perform standard computer tasks, learn new programs/applications with minimal direction
Effective time-management to efficiently plan and sequence and "level-load" or pace the work and experiments by the priority of the project and the time-demands.
Experience in performing all aspects of general lab maintenance including ordering and maintaining laboratory equipment and supplies.
Working knowledge of basic lab safety requirements and EH&S procedures.
Employment is subject to a criminal background check.
Must be willing to work overtime and with a varied work schedule to complete experiments/projects when necessary.
Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral).
UC San Diego Health is the only academic health system in the San Diego region, providing leading-edge care in patient care, biomedical research, education, and community service. Our facilities include two university hospitals, a National Cancer Institute-designated Comprehensive Cancer Center, Shiley Eye Institute, Sulpizio Cardiovascular Center, and several outpatient clinics. UC San Diego Medical Center in Hillcrest is a designated Level I Trauma Center and has the only Burn Center in the county. We invite you to join our dynamic team!
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